uprm.edu  

 
MBRS PROGRAM
Home :: Melendez

Enrique Melendez, Ph.D.

email: emelendez@uprm.edu
Web Page: Enrique Melendez
Current Projects with MBRS-SCORE funds:
Design of metallocene complexes with antitumor properties

Education:

B.S. Chemistry (1983), University of Puerto Rico, PR.
Ph. D. Inorganic Chemistry (1990), University of Utah, UT.

Professional Experience:
2002 – Present:
Professor, Department of Chemistry, University of Puerto Rico, PR.
Summer 2004:
Visiting Faculty, University of Wisconsin, Department of Biochemistry, Madison, WI.
2002-Present:
Managing Editor, Frontiers in BioScience.
2002:
Chairperson, American Chemical Society Puerto Rico Section.
1997-2002: Associate Professor, Department of Chemistry, University of Puerto Rico, PR.
1999 – Present: Director of the Nuclear Magnetic Resonance Facility, University of Puerto Rico, PR.
1994-1997: Director of Nuclear Magnetic Resonance Facility, Inter American University of Puerto Rico, PR.
1994-1997: Associate Professor, Department of Chemistry, InterAmerican University of Puerto Rico, PR .
1991-1994: Assistant Professor, Department of Chemistry, Inter American University of Puerto Rico, PR.
Summer 1993: Visiting Faculty, NSF Summer Program in Solid State Chemistry, Northwestern University, Evanston, IL.
Summer 1992: Visiting Faculty-Minisabbatical, University of Puerto Rico , Rio Piedras, PR .
1992: Research Associate, Department of Chemistry, University of Puerto Rico , Rio Piedras, PR.
1989-1991: Technical Process Scientist, Chemical Development Division, Bristol-Myers Squibb Co. Humacao, PR.
1988-1989: Postdoctoral Associate, Chemical Development Division, Bristol-Myers Squibb Co., Humacao PR.
1984-1988: Graduate Research Assistant, Department of Chemistry, University of Utah, UT.
1984-1987:
Teaching Assistant, Department of Chemistry, University of Utah, UT.

Honors and Awards:

  • Who is Who Among America. 2004

  • Who is Who Among America's Teacher. 1998

  • Outstanding Achievement in Science, Inter American University of Puerto Rico . 1996

  • Outstanding Achievement in Science, Inter American University of Puerto Rico . 1994

  • Outstanding Achievement in Science, Inter American University of Puerto Rico . 1993

  • Productivity Award, Chemical Development Division, Bristol-Myers Squibb Co., Humacao, P.R. 1991

  • Science and Math Award, University of Puerto Rico . 1979

Publications:

  • Tulio E. Chávez-Gil , Enrique Meléndez . "Synthesis, spectroscopic and electrochemical characterization of water soluble
    [( small eta, Greek5-C5H5)2Mo(thionucleobase/thionucleoside)]Cl2 complexes". Inorganica Chimica Acta . Volume 357, Issue 4, March 2004, Pages 1092-1102

  • José L. Vera, Félix R. Román and Enrique Meléndez. "Study of titanocene–DNA and molybdenocene–DNA interactions by inductively coupled plasma–atomic emission spectroscopy". Analytical and Bioanalytical Chemistry. Volume 379, Number 3. June 2004. Pages: 399 - 403.

  • Vilmarí López-Ramos , Carmen A. Vega, Mayra Cádiz and Enrique Meléndez. "Electrochemical and spectroscopic analysis of the interaction of molybdenocene dichloride with nitrogen bases". Journal of Electroanalytical Chemistry .Volume 565, Issue 1 , April 2004, Pages 77-83.

  • Yajaira Pérez, Vilmari López, Luis Rivera-Rivera, Aracelis Cardona and Enrique Meléndez. "Water-soluble titanocene complexes with sulfur-containing aminoacids: synthesis, spectroscopic, electrochemical and Ti(IV)–transferrin interaction studies". Journal of Biological Inorganic Chemistry. Volume 10, Number 2. March 2005. Pages: 94 - 104 .

  • María I. Rodríguez, Tulio Chávez-Gil, Yasiris Colón, Naomi Díaz and Enrique Meléndez. "Molybdenocene–DNA interaction studies using electrochemical analysis". Journal of Electroanalytical Chemistry, Volume 576, Issue 2, March 2005, Pages 315-322.

  • José L. Vera, Félix R. Román and Enrique Meléndez. "Study of titanocene–DNA and molybdenocene–DNA interactions by inductively coupled plasma–atomic emission spectroscopy". Analytical and Bioanalytical Chemistry. Volume 379, Number 3. June 2004. Pages: 399 - 403.

  • “Structure and Redox Behavior of Ru(II)-Diene Complexes, E. Meléndez, V. López, T. Concolino and A.L.Rheingold J. Organometl. Chem. 2004, 689.

  • “Study on carbon-hydrogen activation of ketones by Gold(III) complexes and the synthesis and characterization of two ketonygold(III) complexes D. Fan, E. Meléndez, J.D. Ranford, P.F. Loo and J.J. Vittal J. Organometl. Chem. 2004, 689, 2969-2974.

  • “Electrochemical and spectroscopic characterization analysis of the interaction of molybdenocene dichloride and nitrogen bases” V. López-Ramos, C.A. Vega, M. Cádiz and E. Meléndez J. Electroanal. Chem. 2004, 565, 77-83.

  • “Synthesis, Spectroscopic and Electrochemical Characterization of Water Soluble [5-C5H5)2Mo(Thionucleobase/Thionucleoside)]Cl2 Complexes” T.E. Chávez-Gil and E. Meléndez Inorg. Chim. Acta 2004, 357, 1092-1102.

  • "Titanium Complexes in Cancer Treatment", E. Meléndez, and Invitational Manuscript by Critical Review in Oncology/Hematology, 2002, 42, 309-315.

  • "Kinetics and DNA-metal binding studies of titanocenes antitumor agents", C. Rivera and E. Meléndez, in: Metal Ions in Biology and Medicine; vol 6. Eds J. A. Centeno, Collery, G. Vernet, R. B. Finkelman, H. Gibb, J. C. Ehenne. John Libbey Eurotext, Paris, 2000, pp. 580-584.

  • "Spectroscopic Characterization of Titanocene Complexes with Thionucleobase: Potential Antitumor Agents", E. Meléndez, M. Marrero, C. Rivera, E. Hernández and A. Segal, Inorg. Chem. Acta 2000, 298(2), 176.

  • "Factors Influencing the pKa of Ligated Amines and the Sun/Anti Isomerization In Cysteine-Based Re(V)=O(N2S2) Radio-pharmaceutical Analogues as Revealed by Novel Tautomer in the Solid State", L. Hansen, M. Lipowska, E. Meléndez, X. Xu, S. Hirota, T. Taylor and L. G. Marcilli, Inorg. Chem. 1999, 38, 5351.

  • "Structure of Ru(acac)2(ethoxide)(ethanol)-(½)trans-stilbene", E. Meléndez, I. Guzei and A. L. Rheingold, J. Chem. Cryst. 1999, 29(4), 399.

  • "Ru(acac)2(trans-2,4-hexadiene)•1/6(ethanol) solvate" E. Meléndez, R. Ilarraza, G. P. A. Yap and A. L. Rheingold, Acta Cryst. 1998, C54, 449.

  • "Synthesis and Structure of Ruthenium(II)-Diene Complexes" E. Meléndez, R. Ilarraza, G. P. A. Yap and A. L. Rheingold, J. Organomet. Chem. 1996, 522, 1.

  • "Pentadienyl as Stronger Binding but More Reactive Ligand than Cyclopentadienyl: Synthesis, Reactions and Molecular Orbital Studies of Half-Open Titanocenes", I. Hyla-Kryspin, T. E. Waldman, W. Trakarnpruk, A. M. Arif, M. L. Ziegler, R. D. Ernst and R. Gleiter, Organometallics, 1995, 14, 5030.

  • "Reactions of M(C5H5)Cl4 Complexes (R = H, CH3) with Pentadienyl Anions: Pathways Variations for Niobium vs Tantalum", A. M. Arif, R. D. Ernst, E. Meléndez, A. L. Rheingold, T. E. Waldman, Organometallics, 1995, 14, 1761.

  • "Half-Open Titanocene Chemistry: Coupling Reactions of Pentadienyl Ligand with Carbon-Nitrogen and Carbon-Oxygen Multiple Bonds", T. E. Waldman, A. M. Wilson, A. L. Rheingold, E. Meléndez and R. D. Ernst, Organometallics, 1992, 11, 3201.

  • "cis- and trans-Diene Coordination in Ruthenium(II)-Acetylacetonate Compounds", E. Meléndez, L. Stahl, R. D. Ernst and M. L. Ziegler, Organometallics, 1991, 10, 3635.

  • "Pentadienyl Chemistry of Niobium and Tantalum: Surprising Differences and New Diene and Dienyl Coordination Patterns", E. Meléndez, A. M. Arif, A. L. Rheingold and R. D. Ernst, J. Am. Chem. Soc., 1988, 110, 8703.

  • "Half-Open Titanocene Complexes: Pentadienyl as Both a More Reactive and Strongly Bound Ligand than Cyclopentadienyl", E. Meléndez, A. M. Arif and R. D. Ernst and M. L. Ziegler, Angew. Chem. Int. Ed. Engl. 1988, 27, 1029.



Phone: (787) 834 3165
Fax: (787) 834-3165
e-mail: mbrs[AT]uprm[dot]edu
MBRS-SCORE Program
University of Puerto Rico at Mayagüez
Research and Development Center
Main Building, Office 210
Mayaguez, PR