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Belinda Pastrana-Rios, Ph.D.

email: belinda@uprm.edu
Web Page: Belinda Pastrana-Rios

Current Projects with MBRS-SCORE funds:
Calcium Binding Human Centrosome Proteins & Complexes

Education:

B.S. Chemistry (1987), University of Puerto Rico, Humacao, PR.
M.S. Physical Biochemistry (1991), Rutgers University, Newark, NJ.
Ph.D. Physical Biochemistry (1995), Rutgers University, Newark, NJ.
Posdoctoral Biochem/Mol.Biol/Pharm (1996), Mayo Clinic & Foundation, Rochester, MN.

Professional Experience:
2004-Present: Tenured Professor, Chemistry Department, University of Puerto Rico, Mayagüez, PR.
2002-Present:
Adjunct Professor, Biotechnology, University of Puerto Rico, Mayagüez, PR.
1999-2004:
Associate Professor, Chemistry Department, University of Puerto Rico, Mayagüez, PR.
1996-1999:
Assistant Professor, Chemistry Department, University of Puerto Rico, Mayagüez, PR.
1988-1995:
Research Assistant, Chemistry Department, Rutgers University, Newark, NJ.
1987-1988: Internship as Chemist, Syntex, Humacao, PR.

1984-1987:

Research Assistant, Chemistry Department, University of Puerto Rico, Humacao, PR.

Honors and Awards:

  • Invited attendee, National Academy of Sciences “Self-perpetuating structural state in Biology, Disease and Genetics”. 2002.

  • Sigma Xi nominated member. 2000-Present.

  • NIH-MBRS, University of Puerto Rico, Humacao, Puerto Rico . 1985-1987.

  • NIH-Minority Biomedical Research Support (MBRS) Fellowship, Rutgers University, Newark, New Jersey. 1988-1995.

  • NRSA Postdoctoral Training, Mayo Clinic & Foundation, Rochester, MN . 1995-1996.

  • Mayo Foundation Faculty Scholar, Mayo Clinic & Foundation, Rochester, MN . Summer 1997-1998.

  • Visiting Faculty Award, Mayo Clinic & Foundation, Rochester, MN . Summer 1999.

Publications:

  • Ibon Iloro and Belinda Pastrana-Rios. "Simulation of FT-IR spectra and 2D-COS analysis for the H/D exchange of two related ligands". Journal of Molecular Structure, Volume 799, Issues 1-3, 6 November 2006, Pages 153-157

  • Belinda Pastrana-Rios "Simulation of FT-IR spectra and 2D-COS analysis for the thermal perturbation of apo-centrin". Journal of Molecular Structure, Volume 799, Issues 1-3, 6 November 2006, Pages 163-16.

  • Zuleika Sanoguet, Muriel Campbell, Sindia Ramos, Christina Seda, Luis Pérez Moreno and Belinda Pastrana-Rios. "Effects of Phosphorylation in Chlamydomonas Centrin Ser 167". Calcium Binding Proteins. volume 1. april/may/june 2006. Pages: 108 - 114.

  • Susan M. Meyn, Christina Seda, Muriel Campbell, Kevin L. Weiss, Haitao Hua, Belinda Pastrana-Rios and Walter J. Chazin. "The biochemical effect of Ser167 phosphorylation on Chlamydomonas reinhardtii centrin.". Biochem Biophys Res Commun.2006 Mar 31;342(1):342-348. Epub 2006 Feb 7.

  • Ortiz M, Sanoguet Z, Hu H, Chazin WJ, McMurray C, Salisbury JL, Pastrana-Rios B."Dynamics of hydrogen-deuterium exchange in Chlamydomonas centrin". Biochemistry. 2005 Feb 22;44(7):2409-18.

  • Leslie Villalobos, Yania M. López-Álvarez, Belinda Pastrana-Ríos, and Gustavo E. López. "Thermodynamics of the liquid states of Langmuir monolayers". Received 24 March 2004; accepted 13 December 2004; published online 7 March 2005 .The Journal of Chemical Physics, 8 March 2005. J. Chem. Phys. 122, 104701 (2005) (6 pages)

  • Sanoguet-Carrero, Z., Campbell, M., Lebrón-Rodriguez, R., and Pastrana-Rios, B. “Characterization of Phosphorylated Recombinant Chlamydomonas Centrin” 2004 (Biophysical Journal).

  • Camacho, C., Narvaez, D., Fergusson, K. and Pastrana-Rios, B., “Recombinant sEGFR H/D exchange studies using ATR FT-IR Spectroscopy” 2004 Biophysical Journal.

  • Vélez A. and Pastrana-Rios, B. “Explaining Enzymatic Activity Through Phylogeny in a Cell Biology Course” 2003 (Accepted Molec. Cell. Biol.)

  • Narvaez D., Guillen, N. and Pastrana-Rios, B.”ErbB1 Family of Ligands Fast Hydrogen/Deuterium Exchange kinetics” 2003, Molec. Biol. Cell 14, 13A.

  • Sanoguet Z. and Pastrana-Rios B. 2003 “FT-IR Characterization of Phosphorylated Chlamydomonas Centrin” Biophysical Journal.

  • Narvaez D., Guillen, N. and Pastrana-Rios B. , “TGF-alpha Hydrogen-Deuterium Exchange Dynamics and Kinetcs” (will be submitted to Biochemistry)

  • Sanoguet-Carrero, Z., Campbell, M., Lebrón-Rodriguez, R., and Pastrana-Rios, B. “Relative stability of Phosphorylated Centrin” (will be submitted to J. Biological Chemistry).

  • López, Y., Pastrana-Ríos, B. and López G.E. “Simulation of Adsorption Isotherms” J. Chem. Phys (in Press).

  • Ocasio, M., Maury-Evertsz, J.R., Pastrana-Ríos, B. and López G.E. ”Conformational changes in a model helical peptide: A parallel tempering Monte Carlo study” 2003 J. Chem. Phys. 119, 9274-9279.

  • Pastrana-Rios, B. “Exploring Structure/Function Relationship of Macromolecules at the Undergraduate Level” 2004 J. Chem. Educ. 81, 837-840.

  • Pastrana-Rios, B. , Sanoguet, Z. and Ocaña, W. “Secondary Structure Changes in a Calcium Binding Protein: Centrin” 2002 Advances in Gene Technology: The Genome and Beyond – Structural Biology for Medicine, 13, 34. (peer reviewed short comm.)

  • Pastrana-Rios, B. and López, G. “Mechanism of unfolding of an Alpha-helical Peptide” 2002 Advances in Gene Technology: The Genome and Beyond – Structural Biology for Medicine, 13, 34. (peer reviewed short comm.)

  • Pastrana-Rios, B., Wanda Ocaña, Michelle Rios, German Lorenzo Vargas, Ginny Ysa, Greg Poynter, Javier Tapia, and Salisbury, J. L., "Centrin: Its Secondary Structure in the Presence and Absence of Cations" 2002 Biochemistry 41 (22), 6911-6919.

  • Pastrana-Rios, B. "Understanding the Mechanism of Peptide Unfolding" 2001 Biochemistry, 40, 9074-81.

  • Julianne del Toro, and Belinda Pastrana-Rios, 2001 “Expression of Chlamydomonas centrin monitored via FT-IR Spectroscopy”, Molec. Biol. Cell 12, 27a.

  • Wanda Ocaña Rivera, Belinda Pastrana-Rios, J.L. Salisbury, Walter Chazin, 2001 “Ca2+ and Mg2+ Binding Constants in Chlamydomonas Centrin”, Molec. Biol. Cell 12, 27a.

  • Mildred Ortiz, Belinda Pastrana, Haitao Hu, Walter Chazin, 2001 “H/D Exchange FT-IR Spectroscopic Study of Chlamydomonas Centrin Domains” Molec. Biol. Cell 12, 27a.

  • Pastrana-Rios, B. “Biochemistry Laboratory II”, URL site: http://www.uprm.edu/wquim/q5074, 2001 (copyright).

  • Pastrana-Rios, B. “Using InsightII® to Provide an Interdisciplinary Approach for Teaching Structural Biology” Accelrys 2002.

  • Graff, D. K., Pastrana-Rios, B., Venyaminov, S., Prendergast, F.G., "Fourier Transform Infrared Spectroscopy and Two-Dimensional Infrared Analysis of Model Helical Peptides" 1997 Journal of the American Chemical Society, 119, 11282-11294.



Phone: (787) 834 3165
Fax: (787) 834-3165
e-mail: mbrs[AT]uprm[dot]edu
MBRS-SCORE Program
University of Puerto Rico at Mayagüez
Research and Development Center
Main Building, Office 210
Mayaguez, PR