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Breakdown Kinetics in Human Stomach for Drug Delivery Matrices--Desintegration Kinetics of Drug Delivery Matrices in Human Stomach

Dr. Bo Hu, Ph.D


Oral drug delivery to the gastrointestinal (GI) tract is heavily researched and commercialized for various pharmaceuticals with different delivery systems. The USP dissolution tests are commonly used to simulate gastrointestinal (GI) conditions; however, in vivo drug release for hydrogel-type tablets was found in most cases much faster than that expected from in vitro dissolution tests. The lack of in vivo-in vitro correlation is possibly caused by the mechanical stress, received by the peristaltic movement of the GI wall. Recently, an innovative in vitro stomach system was developed at Food Engineering Department at UC Davis, which provides and monitors various mechanical forces present in the human stomach acting on food samples and drug tablets. This project, which incorporates this new food digestion model into current oral drug delivery systems, will explain the common in vitro-in vivo disintegrity for current hydrogel oral drug GI delivery system, and will provide the preliminary results for a full NIH proposal to develop a standard procedure for across-the-board in vitro release research from oral drug delivery systems. The hypothesis of the project is: considering the mechanical forces into current USP dissolution method, the in vivo oral drug release behavior will be able to be estimated with in vitro experiments.

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