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Nucleotide variations at the insulin-like growth factor binding Protein-2 (IGFBP-2) gene locus might be associated with a cell proliferative phenotype

Melvin Pagan, Ph.D


The insulin-like growth factor (IGF) axis represents one of the most important families of proteins associated with the growth and development of animals. One of its members, IGFBP-2 has been implicated as a negative regulator of somatic growth in lower and higher vertebrates. Current research focuses on the role of this protein in normal and abnormal cell proliferation (cancer) based on its expression (mRNA, protein). However, in bovines the IGFBP-2 gene is highly polymorphic. Therefore, it is imperative to elucidate if differences in the nucleotide sequence of that gene are responsible of variations in expression which ultimately would affect cell growth and organogenesis. To study that hypothesis we are proposing to establish a bovine cell culture system using cells differing in IGFBP-2 genotype/haplotype to evaluate their proliferation pattern.

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