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Magnetite Nanoparticle Cytotoxicity and Transport in Caco-2 Cells with Aplications in Magnetocytolysis

Carlos Rinaldi Ph.D.


An Interesting potential clinical application of magnetic fluids is magnetocytolysis, or targeted cell destruction. This is also referred to as magnetic fluid hyperthermia, though is should be noted that the treatment schemes proposed in the literature do not result in significant temperature increases above systolic levels.

Magnetic nanoparticles delivered and concentrated at a target site, such as a cancerous tumor, are made to rotate through an externally imposed alternating or rotating magnetic field. Though magnetocytolysis has been shown to induce tumor cell death, work is still required to elucidate the mechanisms underlying this effect.

Such knowledge would be instrumental in further developing this technique for clinical treatment of malignant tumors. The focus of this proposal is to perform preliminary studies of magnetite nanoparticle transport in colon cancer (Caco-2) cells and eventually to induce magnetocytolysis using an oscillating magnetic field. These studies will form the basis for a larger proposal to be submitted to NIH in December 2005.

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